IBD IBD Pathophysiology 3

Question 1

Which molecule primarily mediates lymphocyte trafficking to the gut mucosa and is targeted by vedolizumab?

Accepted Answer

MAdCAM-1 / α4β7 integrin

Answer

VCAM-1 / α4β1 integrin

Answer

ICAM-1 / LFA-1

Answer

E-selectin / PSGL-1

Question 2

Dysbiosis in IBD most commonly involves a reduction in which beneficial bacterial genus?

Accepted Answer

Faecalibacterium

Answer

Clostridioides

Answer

Fusobacterium

Answer

Escherichia

Question 3

Which prostaglandin pathway, when upregulated in IBD, contributes to mucosal inflammation and diarrhea?

Accepted Answer

COX-2 / PGE2 pathway

Answer

LOX / LTB4 pathway

Answer

5-HPETE pathway

Answer

Thromboxane A2 pathway

Question 4

The JAK-STAT signaling pathway in IBD is targeted by which class of medications?

Accepted Answer

JAK inhibitors (e.g., tofacitinib)

Answer

Anti-TNF monoclonal antibodies

Answer

Anti-integrin antibodies

Answer

Aminosalicylates

Question 5

Paneth cells in the small intestine contribute to IBD pathogenesis primarily through which mechanism?

Accepted Answer

Secreting defensins and antimicrobial peptides that are impaired in Crohn's

Answer

Producing excessive mucus

Answer

Absorbing fat-soluble vitamins

Answer

Generating bile acids

Question 6

Which IBD-associated antibody is most specific for Crohn's disease?

Accepted Answer

ASCA (anti-Saccharomyces cerevisiae antibody)

Answer

pANCA (perinuclear antineutrophil cytoplasmic antibody)

Answer

Anti-dsDNA

Answer

Anti-Smith antibody