FREE Pharmacology Drug Absorption, Distribution, Metabolism Questions and Answers

Question 1

A highly lipophilic drug is administered orally. Which of the following factors would most significantly enhance its absorption across the gastrointestinal membrane?

Accepted Answer

Increased blood flow to the absorption site

Answer

Presence of P-glycoprotein efflux pumps

Answer

High degree of ionization at physiological pH

Answer

Co-administration with a gastric acid suppressor

Question 2

Which phase of drug metabolism typically involves the introduction or unmasking of polar functional groups, making the drug more amenable to subsequent conjugation reactions?

Accepted Answer

Phase I reactions

Answer

Phase IV reactions

Answer

Phase III reactions

Answer

Phase II reactions

Question 3

A patient with severe liver cirrhosis is prescribed a drug that undergoes extensive first-pass metabolism. What adjustment might be necessary for the prescribed dose to avoid toxicity?

Accepted Answer

Decrease the oral dose or choose an alternative administration route.

Answer

Increase the oral dose to compensate for reduced absorption.

Answer

Maintain the standard oral dose as liver function primarily affects excretion.

Answer

Administer the drug intravenously at a higher dose.

Question 4

Which of the following drug characteristics would lead to the highest volume of distribution (Vd)?

Accepted Answer

High lipid solubility and extensive tissue binding.

Answer

High plasma protein binding and high water solubility.

Answer

Low lipid solubility and high molecular weight.

Answer

Rapid renal excretion and low protein binding.

Question 5

A drug is a substrate for the CYP3A4 enzyme. Co-administration with a potent CYP3A4 inhibitor would likely result in which of the following?

Accepted Answer

Increased plasma concentration of the drug.

Answer

Decreased plasma concentration of the drug.

Answer

No significant change in drug metabolism.

Answer

Increased renal clearance of the drug.

Question 6

What is the primary mechanism by which drugs are absorbed from the gastrointestinal tract if they are small, lipophilic, and uncharged?

Accepted Answer

Passive diffusion

Answer

Active transport

Answer

Facilitated diffusion

Answer

Pinocytosis

A highly lipophilic drug is administered orally.Which of the following factors would most significantly enhance its absorption across the gastrointestinal membrane?

A highly lipophilic drug is administered orally.
Which of the following factors would most significantly enhance its absorption across the gastrointestinal membrane?