MTM Pharmacotherapy Review & Drug Interactions

Question 1

Which of the following medications is most likely to cause a serious drug interaction with warfarin?

Accepted Answer

Amiodarone

Answer

Acetaminophen

Answer

Simvastatin

Answer

Lisinopril

Question 2

What is the primary concern when combining an ACE inhibitor with a potassium-sparing diuretic?

Accepted Answer

Hyperkalemia

Answer

Increased sodium retention

Answer

Hypokalemia

Answer

Bradycardia

Question 3

Which medication is a strong CYP3A4 inhibitor that can increase serum levels of statins?

Accepted Answer

Ketoconazole

Answer

Metformin

Answer

Aspirin

Answer

Hydrochlorothiazide

Question 4

Which pharmacokinetic interaction occurs when omeprazole is taken with clopidogrel?

Accepted Answer

Reduced clopidogrel efficacy

Answer

Increased clopidogrel activation

Answer

Increased bleeding risk

Answer

No interaction

Question 5

Which class of antidepressants is most associated with significant drug-drug interactions?

Accepted Answer

MAO inhibitors

Answer

SSRIs

Answer

SNRIs

Answer

Tricyclic antidepressants

Question 6

What type of drug interaction occurs when a medication affects the excretion of another?

Accepted Answer

Pharmacokinetic

Answer

Pharmacodynamic

Answer

Synergistic

Answer

Antagonistic

Question 7

Which drug is known to decrease the effectiveness of oral contraceptives?

Accepted Answer

Rifampin

Answer

Amoxicillin

Answer

Azithromycin

Answer

Cefuroxime

Question 8

Which of the following increases the risk of serotonin syndrome when used with SSRIs?

Accepted Answer

Tramadol

Answer

Acetaminophen

Answer

Ibuprofen

Answer

Loratadine

Question 9

Which interaction is likely when NSAIDs are combined with antihypertensive medications?

Accepted Answer

Reduced efficacy of antihypertensives

Answer

Improved blood pressure control

Answer

Reduced blood pressure

Answer

No change in blood pressure