KAPS Pharmacology and Therapeutics 1

Question 1

Which receptor type does acetylcholine primarily act on in the parasympathetic nervous system?

Accepted Answer

Muscarinic

Answer

Acetylcholine is the primary neurotransmitter of the parasympathetic nervous system. In this system, it primarily acts on muscarinic receptors, which are G-protein coupled receptors found on target organs like the heart, smooth muscle, and glands. Activation of these receptors mediates the 'rest and digest' responses characteristic of parasympathetic activity.

Question 2

What is the primary mechanism of action of beta-blockers in treating hypertension?

Accepted Answer

Reducing heart rate and cardiac output

Answer

Beta-blockers primarily treat hypertension by blocking beta-adrenergic receptors, particularly beta-1 receptors in the heart. This blockade leads to a decrease in heart rate and myocardial contractility, which in turn reduces the heart's overall workload and cardiac output. Consequently, the blood pressure is lowered, making them effective antihypertensive agents.

Question 3

Which class of drugs is most effective in managing acute asthma attacks?

Accepted Answer

Short-acting beta-agonists

Answer

Short-acting beta-agonists (SABAs), such as albuterol, are the most effective class of drugs for managing acute asthma attacks. They work by rapidly relaxing the smooth muscles in the airways, leading to bronchodilation and immediate relief of symptoms like wheezing and shortness of breath. Their quick onset of action makes them crucial 'rescue' medications for acute exacerbations.

Question 4

What is the main adverse effect of aminoglycosides?

Accepted Answer

Nephrotoxicity and ototoxicity

Answer

Aminoglycosides are a class of antibiotics known for their significant adverse effects on the kidneys (nephrotoxicity) and inner ear (ototoxicity). These drugs accumulate in renal tubular cells and the hair cells of the cochlea and vestibular system, leading to cellular damage and impaired function. Close monitoring of renal function and hearing is essential during aminoglycoside therapy to mitigate these risks.

Question 5

Which anticoagulant works by directly inhibiting thrombin?

Accepted Answer

Dabigatran

Answer

Dabigatran is a direct thrombin inhibitor (DTI) that works by directly binding to and inhibiting both free and clot-bound thrombin. Thrombin is a crucial enzyme in the coagulation cascade, responsible for converting fibrinogen to fibrin, which forms the structural mesh of a blood clot. By inhibiting thrombin, dabigatran effectively prevents the formation of new clots and the extension of existing ones.

(KAPS) Knowledge Assessment of Pharmaceutical Sciences Practice Test

(KAPS) Knowledge Assessment of Pharmaceutical Sciences Practice Test

KAPS Pharmacology and Therapeutics 1