FREE Internal Medicine Gastroenterology and Hepatology Questions and Answers

Question 1

A 48-year-old male with a history of iron deficiency anemia and intermittent bloating presents for evaluation.
He reports no significant alcohol use or medication changes.
Which of the following is the most appropriate initial serologic test to screen for celiac disease?

Accepted Answer

IgA anti-tissue transglutaminase (tTG) antibody

Answer

Anti-saccharomyces cerevisiae antibodies (ASCA)

Answer

Endoscopy with duodenal biopsy

Answer

Hydrogen breath test

Question 2

A patient's hepatitis B serology results are as follows: HBsAg: Negative, Anti-HBs: Positive, Anti-HBc (Total): Positive, IgM Anti-HBc: Negative. What is the correct interpretation of these results?

Accepted Answer

Immunity due to resolved natural infection

Answer

Immunity due to hepatitis B vaccination

Answer

Acute hepatitis B infection

Answer

Chronic hepatitis B infection

Question 3

A 65-year-old male with decompensated cirrhosis due to alcohol use presents with moderate, new-onset ascites. His renal function is normal, and his serum potassium is 4.2 mEq/L. According to current guidelines, what is the most appropriate initial diuretic regimen?

Accepted Answer

Spironolactone 100 mg and furosemide 40 mg daily

Answer

Furosemide 40 mg daily

Answer

Spironolactone 25 mg daily

Answer

Metolazone 5 mg daily

Question 4

A 34-year-old female is diagnosed with moderate-to-severe ulcerative colitis. She has failed to respond to a course of oral and rectal mesalamine and required a course of corticosteroids for a recent flare. Which of the following medication classes is an appropriate next step for inducing and maintaining remission?

Accepted Answer

An anti-TNF biologic agent (e.g., infliximab)

Answer

Loperamide

Answer

A proton pump inhibitor (e.g., omeprazole)

Answer

An antibiotic (e.g., ciprofloxacin)

Question 5

According to the most recent guidelines from the U.S. Preventive Services Task Force (USPSTF) and the American Cancer Society (ACS), at what age should asymptomatic individuals with an average risk for colorectal cancer begin screening?

Accepted Answer

45

Answer

50

Answer

40

Answer

55

Question 6

A 59-year-old patient on treatment for latent tuberculosis with isoniazid develops fatigue, nausea, and right upper quadrant discomfort. Laboratory tests reveal an AST of 350 U/L and an ALT of 410 U/L (baseline was normal). Which of the following patterns of liver injury is most characteristically associated with isoniazid toxicity?

Accepted Answer

Hepatocellular injury

Answer

Cholestatic injury

Answer

Granulomatous hepatitis

Answer

Nodular regenerative hyperplasia

A 48-year-old male with a history of iron deficiency anemia and intermittent bloating presents for evaluation.He reports no significant alcohol use or medication changes.Which of the following is the most appropriate initial serologic test to screen for celiac disease?

A 48-year-old male with a history of iron deficiency anemia and intermittent bloating presents for evaluation.
He reports no significant alcohol use or medication changes.
Which of the following is the most appropriate initial serologic test to screen for celiac disease?