Family Nurse Practitioner Test Cheat Sheet 2026

The 30 highest-yield Family Nurse Practitioner Test facts, distilled from real exam questions. Print it, save it as a PDF, or study it here — free, no sign-up.

1. When auscultating the abdomen, the FNP hears a bruit over the renal artery. This finding suggests: → Renal artery stenosis
2. A patient on chronic NSAIDs develops a peptic ulcer. Which is the MOST appropriate gastroprotective co-therapy? → Proton pump inhibitor (e.g., omeprazole)
3. Which vaccine is contraindicated in a pregnant woman at 20 weeks gestation? → MMR
4. During a pediatric well-visit, the FNP assesses a 6-month-old and notes absence of the Moro reflex. This finding is MOST concerning for: → Central nervous system dysfunction
5. Alpha blockers are more prevalent among Southeast Asians of Indian, Chinese, or Filipino descent? → False
6. Which of the following neoplasms is considered to be benign? → Leiomyoma
7. A mother brings her 18-month-old with fever, bulging anterior fontanelle, and irritability. Which diagnosis must be ruled out immediately? → Bacterial meningitis
8. Which of the following best describes tertiary prevention in the context of a patient with heart failure? → Cardiac rehabilitation and medication adherence to prevent hospitalization
9. The FNP prescribes an oral fluoroquinolone. Which patient education point is MOST critical? → Avoid antacids within 2 hours of the dose and report tendon pain immediately
10. The FNP is counseling a postmenopausal woman on hormone therapy (HT). Which combination is preferred for a woman WITH a uterus? → Estrogen plus progestogen (combined HT)
11. Which of the following is the most appropriate initial antibiotic for uncomplicated community-acquired pneumonia in a healthy adult without comorbidities? → Azithromycin or doxycycline
12. A patient on fluoxetine is prescribed tramadol for pain. The FNP's GREATEST concern is: → Serotonin syndrome
13. A patient with COPD exacerbation is found to have pursed-lip breathing. This compensatory mechanism primarily serves to: → Slow exhalation to maintain airway pressure and prevent early airway collapse
14. The FNP prescribes isotretinoin for a female patient with severe acne. Which MANDATORY program must the patient be enrolled in? → iPLEDGE
15. A patient has a fasting plasma glucose of 128 mg/dL on two separate occasions. The FNP diagnoses: → Diabetes mellitus
16. A 25-year-old male presents with urethral discharge and dysuria. Gram stain shows intracellular gram-negative diplococci. What is the first-line treatment? → Ceftriaxone 500mg IM single dose plus doxycycline 100mg twice daily for 7 days
17. A patient's Weber test shows lateralization to the LEFT ear. Which interpretation is MOST accurate? → Conductive hearing loss in the left ear OR sensorineural loss in the right ear
18. In clinical management, evidence-based practice is based on _____. → systematic reviews
19. What statement about mitral regurgitation is correct? → It may be noted as a holosystolic murmur.
20. Tina, a 34-year-old AIDS patient, is experiencing diarrhea right now. What kind of protozoal infection of the bowel do you think she has? → Cryptosporidiosis
21. B12 deficiency anemia causes which of these symptoms? → Tingling and numbness of both feet
22. The family nurse practitioner will have the patient make quick, alternating movements with their hands to test for: → Cerebellar functioning
23. A patient with atrial fibrillation is started on digoxin. The FNP should counsel the patient to report which EARLY sign of toxicity? → Nausea, vomiting, and visual disturbances
24. Which patient would you recommend getting the HPV vaccine for? → Sally, age 17, who had a baby 6 months ago and is breastfeeding.
25. In primary care, which of the following laboratory tests is used to assess renal function? → Creatinine
26. An anterior nosebleed will develop from injury to the Kiesselbach's plexus. → Correct
27. When a patient is being examined physically, the facial nerve's health can be determined by asking them to: → puff out both cheeks
28. Which physical exam finding is most consistent with aortic stenosis? → Harsh systolic crescendo-decrescendo murmur at the right upper sternal border
29. A 32-year-old woman at 28 weeks gestation screens positive on the 1-hour glucose challenge test (152 mg/dL). What is the next appropriate step? → Perform a 3-hour 100g oral glucose tolerance test
30. The FNP is conducting a sports physical for a 16-year-old. Which finding warrants DISQUALIFICATION from contact sports? → Single functional kidney