DO Pharmacology and Therapeutics 3

Question 1

Which class of drugs for COPD works by blocking muscarinic receptors to cause bronchodilation?

Accepted Answer

Long-acting muscarinic antagonists (LAMAs)

Answer

Long-acting beta-2 agonists (LABAs)

Answer

Inhaled corticosteroids (ICS)

Answer

Phosphodiesterase-4 inhibitors

Question 2

A 28-year-old woman with bipolar disorder is planning pregnancy. Which mood stabilizer poses the GREATEST teratogenic risk?

Accepted Answer

Valproate

Answer

Lamotrigine

Answer

Lithium

Answer

Quetiapine

Question 3

Which medication used for alcohol use disorder works by causing an aversive reaction when alcohol is consumed (disulfiram-like effect)?

Accepted Answer

Disulfiram

Answer

Naltrexone

Answer

Acamprosate

Answer

Bupropion

Question 4

Thiazide diuretics cause which electrolyte abnormality as a common side effect?

Accepted Answer

Hypokalemia

Answer

Hyperkalemia

Answer

Hypernatremia

Answer

Hypercalcemia

Question 5

Which drug class is used to treat opioid-induced constipation by acting as a peripherally restricted mu-opioid receptor antagonist?

Accepted Answer

Methylnaltrexone (PAMORA)

Answer

Bisacodyl

Answer

Polyethylene glycol

Answer

Docusate sodium

Question 6

Clopidogrel is a prodrug that requires activation by which enzyme system to inhibit platelet aggregation?

Accepted Answer

CYP2C19

Answer

CYP3A4

Answer

CYP2D6

Answer

CYP1A2