DHA Pharmacist 5

Question 1

A patient with a creatinine clearance of 25 mL/min is prescribed a renally cleared antibiotic. What dose adjustment strategy is most appropriate?

Accepted Answer

Reduce the dose, extend the dosing interval, or both

Answer

For renally cleared drugs, dose reduction and/or interval extension is necessary in renal impairment to prevent drug accumulation and toxicity.

Question 2

Which controlled substance schedule under UAE law includes drugs with accepted medical use but high potential for abuse, such as morphine?

Accepted Answer

Table I (First Schedule)

Answer

Under UAE Federal Law No. 14 of 1995, morphine and similar opioids are classified under the First Schedule (Table I), which governs narcotics with strict prescribing requirements.

Question 3

A pharmacist receives a prescription for sildenafil for a patient who is also taking isosorbide mononitrate. What should the pharmacist do?

Accepted Answer

Refuse to dispense sildenafil and contact the prescriber immediately

Answer

The combination of PDE5 inhibitors with nitrates is absolutely contraindicated due to severe hypotension risk; the pharmacist must withhold dispensing and contact the prescriber.

Question 4

What is the primary advantage of using the AUC (area under the concentration-time curve) to measure drug exposure?

Accepted Answer

It provides a measure of total systemic drug exposure over time

Answer

AUC represents the total drug exposure over time and is used to compare bioavailability, calculate clearance, and guide dosing decisions.

Question 5

A patient taking lithium for bipolar disorder is started on hydrochlorothiazide. What monitoring is most critical?

Accepted Answer

Serum lithium levels for toxicity

Answer

Thiazide diuretics reduce renal sodium and lithium excretion, increasing lithium serum levels and the risk of lithium toxicity.

DHA - Dubai Health Authority Practice Test

DHA - Dubai Health Authority Practice Test

DHA Pharmacist 5