DHA Pharmacist Pharmaceutical Sciences

Question 1

Which pharmacokinetic parameter describes the fraction of an administered drug dose that reaches systemic circulation unchanged?

Accepted Answer

Bioavailability (F)

Answer

Volume of distribution (Vd)

Answer

Clearance (CL)

Answer

Half-life (t½)

Question 2

What is the primary site of drug metabolism in the body?

Accepted Answer

Liver

Answer

Kidney

Answer

Lung

Answer

Small intestine only

Question 3

Which drug formulation property determines whether a tablet should NOT be crushed?

Accepted Answer

Extended-release (ER/XR) coating or enteric coating

Answer

Standard immediate-release coating

Answer

Plain sugar coating

Answer

Coloured coating only

Question 4

What is the Henderson-Hasselbalch equation used for in pharmacy?

Accepted Answer

Calculating the degree of ionisation of a drug at a given pH

Answer

Calculating dose adjustments in renal failure

Answer

Determining drug storage temperature

Answer

Estimating bioavailability

Question 5

Which process describes the elimination of a drug from the body at a constant fraction per unit time, regardless of plasma concentration?

Accepted Answer

First-order elimination kinetics

Answer

Zero-order elimination kinetics

Answer

Michaelis-Menten kinetics

Answer

Saturation kinetics

Question 6

Which factor most significantly affects the volume of distribution (Vd) of a highly lipophilic drug?

Accepted Answer

Extensive distribution into adipose and peripheral tissues resulting in a large Vd

Answer

High plasma protein binding causing a small Vd

Answer

Rapid renal excretion limiting distribution

Answer

Water solubility causing restriction to plasma only