Dermatologist Certificate Dermatopathology and Histology 3

Question 1

Verocay bodies are a histological feature associated with which cutaneous tumor?

Accepted Answer

Schwannoma (neurilemmoma)

Answer

Neurofibroma

Answer

Granular cell tumor

Answer

Dermatofibroma

Question 2

Solar elastosis is characterized by which histological finding in the dermis?

Accepted Answer

Basophilic degeneration and clumping of elastic fibers

Answer

Increased fibrotic collagen deposition

Answer

Granulomatous inflammation with giant cells

Answer

Mucin deposition in the reticular dermis

Question 3

Which direct immunofluorescence pattern is characteristic of pemphigus vulgaris?

Accepted Answer

Intercellular IgG in a 'chicken wire' pattern

Answer

Linear IgG and C3 at the basement membrane zone

Answer

Granular IgA deposits in dermal papillae

Answer

Granular IgM at the dermal-epidermal junction

Question 4

Which histochemical stain is most useful for identifying amyloid deposits in the skin, and what is its characteristic finding under polarized light?

Accepted Answer

Congo red stain showing apple-green birefringence

Answer

PAS stain showing magenta coloration

Answer

Alcian blue showing blue mucin deposits

Answer

Masson trichrome showing green collagen

Question 5

Palisading granulomas with central necrobiosis of collagen and mucin are the histological hallmark of which condition?

Accepted Answer

Granuloma annulare

Answer

Sarcoidosis

Answer

Foreign body granuloma

Answer

Lepromatous leprosy

Question 6

'Naked granulomas' (non-caseating granulomas with sparse surrounding lymphocytes) in skin biopsies are characteristic of which systemic condition?

Accepted Answer

Sarcoidosis

Answer

Crohn's disease with cutaneous involvement

Answer

Granuloma annulare

Answer

Rheumatoid nodule

Question 7

Which histological feature best characterizes Kaposi sarcoma and distinguishes it from other vascular tumors?

Accepted Answer

Slit-like vascular spaces with spindle cells and extravasated erythrocytes

Answer

Epithelioid endothelial cells with hobnail morphology

Answer

Glomeruloid vascular structures within dermal nodules

Answer

Cavernous dilated vascular channels lined by flat endothelium