DEA DEA Pharmacology and Drug Effects

Question 1

What is the primary mechanism of action of opioids at the cellular level?

Accepted Answer

They bind to mu, kappa, and delta opioid receptors

Answer

They block dopamine reuptake in the synapse

Answer

They enhance serotonin release throughout the CNS

Answer

They inhibit acetylcholinesterase activity

Question 2

Which neurotransmitter is primarily responsible for cocaine's intense euphoric effects?

Accepted Answer

Dopamine

Answer

Serotonin

Answer

GABA

Answer

Norepinephrine

Question 3

What pharmacological term describes the need for increasing doses of a drug to achieve the same effect over time?

Accepted Answer

Tolerance

Answer

Physical dependence

Answer

Withdrawal syndrome

Answer

Cross-sensitization

Question 4

Which drug class works primarily by enhancing GABA inhibitory activity at the GABA-A receptor?

Accepted Answer

Benzodiazepines

Answer

Opioids

Answer

Amphetamines

Answer

Hallucinogens

Question 5

Which synthetic opioid is approximately 100 times more potent than morphine by weight?

Accepted Answer

Fentanyl

Answer

Oxycodone

Answer

Hydromorphone

Answer

Hydrocodone

Question 6

What term describes the physiological symptoms that occur when a chronically used drug is abruptly discontinued?

Accepted Answer

Withdrawal syndrome

Answer

Drug tolerance

Answer

Pharmacological potentiation

Answer

Receptor sensitization

Question 7

Which route of drug administration typically produces the fastest onset of pharmacological effects?

Accepted Answer

Intravenous injection

Answer

Oral ingestion

Answer

Intramuscular injection

Answer

Transdermal patch