When treating a dog with chronic osteoarthritis using acupuncture, which neurophysiological mechanism is MOST important for achieving long-term pain relief beyond the treatment session?
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A
Acute endorphin release occurring only during needle retention time
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B
Mechanical compression of nociceptive nerve fibers by the needle
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C
Neuroplasticity and long-term modulation of central pain processing circuits
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D
Permanent destruction of cartilage-innervating nociceptive afferents