Practice Test Geeks(CTP) Certified Transplant Preservationist Practice Test
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Organ Preservation Techniques Flashcards

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  1. Which mechanism primarily drives reperfusion injury after cold ischemia?

    Answer: Reactive oxygen species (ROS) burst from xanthine oxidase activation

    Xanthine oxidase converts hypoxanthine to uric acid upon oxygen reintroduction, generating a burst of ROS that damages cell membranes.

  2. What is the main advantage of Custodiol HTK (histidine-tryptophan-ketoglutarate) solution over UW solution for cardiac preservation?

    Answer: Lower viscosity allowing better coronary perfusion

    HTK's low viscosity enables more uniform and complete coronary distribution compared to the more viscous UW solution.

  3. In the context of donation after circulatory death (DCD), what distinguishes 'warm ischemia time' from 'functional warm ischemia time'?

    Answer: Functional warm ischemia begins when SBP <50 mmHg or SpO₂ <70%, not at circulatory arrest

    Functional warm ischemia starts when perfusion becomes inadequate (SBP <50 or SpO₂ <70%), capturing the period of physiologically significant ischemia before arrest.

  4. Which kidney machine perfusion parameter most accurately predicts post-transplant function?

    Answer: Resistive index (RI)

    The resistive index reflects vascular resistance in the kidney and is the most validated perfusion parameter for predicting delayed graft function.

  5. Why is Celsior solution particularly favored for heart and lung preservation?

    Answer: It contains high concentrations of histidine for buffering and mannitol as an osmotic agent

    Celsior's histidine buffering capacity and mannitol-based osmolarity make it well-suited for thoracic organ preservation.

  6. During hypothermic oxygenated machine perfusion (HOPE) of the liver, oxygen is supplied primarily to:

    Answer: Reverse mitochondrial damage and restore energy stores

    HOPE uses low-level oxygenation at hypothermic temperatures to restore mitochondrial function and replenish ATP before transplant.

  7. Which electrolyte concentration in University of Wisconsin solution helps prevent cellular swelling by limiting sodium entry?

    Answer: High potassium (125 mEq/L)

    UW solution's high potassium concentration mimics the intracellular environment, reducing the electrochemical gradient that drives sodium and water into cells.