CTBS Donor Screening & Eligibility 3

Question 1

Which of the following serological testing results would render a tissue donor ineligible under FDA regulations regardless of other findings?

Accepted Answer

Repeatedly reactive HIV-1 NAT

Answer

A repeatedly reactive HIV-1 NAT result confirms viral nucleic acid presence and is an absolute contraindication for tissue donation.

Question 2

For tissue donors who die from drowning, which of the following is a primary concern related to blood specimen integrity?

Accepted Answer

Hemodilution may compromise serological test accuracy

Answer

Hemodilution from fluid resuscitation or drowning can dilute antibody concentrations below assay detection thresholds, potentially yielding false-negative serology.

Question 3

A tissue donor received 2 units of packed red blood cells 24 hours before death. Which step is required before determining serological test validity?

Accepted Answer

Apply a hemodilution algorithm to assess specimen dilution

Answer

AATB standards require applying an FDA-accepted hemodilution algorithm to determine whether transfusion compromised specimen integrity before accepting serological results.

Question 4

Cytomegalovirus (CMV) serology is routinely tested in tissue donors primarily to:

Accepted Answer

Provide CMV status information to guide recipient selection by transplant physicians

Answer

CMV serology is used to inform transplant physicians about donor CMV status so they can match donors and recipients appropriately, especially for immunocompromised patients.

Question 5

Under AATB standards, a tissue bank receives a donor specimen with a repeatedly reactive HBsAg result. The neutralization confirmatory test is negative. The donor should be:

Accepted Answer

Considered ineligible because HBsAg was repeatedly reactive regardless of confirmatory result

Answer

Per FDA and AATB standards, a repeatedly reactive HBsAg screening test result renders the donor ineligible, even if a supplemental test is negative.

(CTBS) Certified Tissue Bank Specialist Practice Test

(CTBS) Certified Tissue Bank Specialist Practice Test

CTBS Donor Screening & Eligibility 3