CSPT Medication and Component Handling 4

Question 1

When receiving a shipment of APIs for sterile compounding, which action is most critical before accepting the materials?

Accepted Answer

Verify COA matches the purchase order specifications

Answer

A Certificate of Analysis (COA) must be verified against purchase order specifications to confirm identity, purity, and potency before accepting any API shipment.

Question 2

Which storage condition is required for most reconstituted protein-based injectable medications?

Accepted Answer

Refrigerated (2–8°C)

Answer

Most reconstituted protein-based injectables require refrigeration at 2–8°C to prevent protein degradation and maintain potency.

Question 3

A technician notices that a vial of vancomycin powder for injection has turned slightly yellow. What is the appropriate action?

Accepted Answer

Quarantine the vial and report to the pharmacist

Answer

Any visual change in an API or drug product is grounds for quarantine and pharmacist evaluation, as discoloration may indicate degradation.

Question 4

Under USP <797>, which beyond-use date (BUD) category applies to a Category 1 compounded sterile preparation?

Accepted Answer

12 hours at room temperature or 24 hours refrigerated

Answer

USP <797> Category 1 CSPs have a BUD of 12 hours at controlled room temperature or 24 hours refrigerated.

Question 5

Which technique is used to transfer a hazardous drug from a vial to a syringe while maintaining negative pressure?

Accepted Answer

Using a closed-system drug transfer device (CSTD)

Answer

Closed-system drug transfer devices (CSTDs) mechanically prohibit the transfer of environmental contaminants and prevent aerosol or liquid escape when handling hazardous drugs.

CSPT - Compounded Sterile Preparation Technician Practice Test

CSPT - Compounded Sterile Preparation Technician Practice Test

CSPT Medication and Component Handling 4