A 15-year-old male patient with Crohn's disease presents with growth failure. Compared to a healthy peer, his linear growth deficit is most likely driven by which primary mechanism?
-
A
Excessive glucocorticoid use causing growth plate suppression
-
B
Chronic inflammation suppressing IGF-1 and increasing catabolic cytokines
-
C
Malabsorption of vitamin D causing rickets
-
D
Hyperthyroidism secondary to inflammatory bowel disease