Specialty Drug Therapies & Disease Management Flashcards
7 cards from real CSP practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Specialty Drug Therapies & Disease Management flashcards as text
Imatinib exerts its therapeutic effect in chronic myeloid leukemia primarily by inhibiting which target?
Answer: BCR-ABL tyrosine kinase
Imatinib inhibits the constitutively active BCR-ABL tyrosine kinase produced by the Philadelphia chromosome.
Which oral chemotherapy agent carries a boxed warning for increased bleeding risk and INR elevation when given with warfarin?
Answer: Capecitabine
Capecitabine can markedly raise INR in patients on warfarin, so frequent INR monitoring is required.
Before lenalidomide can be dispensed, which requirement must be satisfied?
Answer: Prescriber, patient, and pharmacy must be enrolled in the lenalidomide REMS program
Lenalidomide is distributed under a REMS due to embryo-fetal toxicity, requiring certified prescribers, pharmacies, and enrolled patients.
A patient with CLL on ibrutinib reports palpitations. Which adverse effect of ibrutinib is most likely responsible?
Answer: Atrial fibrillation
Ibrutinib is associated with atrial fibrillation and bleeding risk.
Osimertinib is preferred in non-small cell lung cancer harboring which mutation, including resistance mutations?
Answer: EGFR mutations including T790M
Osimertinib is a third-generation EGFR TKI active against sensitizing EGFR mutations and T790M resistance.
In sickle cell disease, hydroxyurea reduces painful crises mainly by which mechanism?
Answer: Increasing fetal hemoglobin production
Hydroxyurea increases HbF, which reduces HbS polymerization and sickling.
Which statement best describes emicizumab for hemophilia A?
Answer: A subcutaneous bispecific antibody that mimics factor VIIIa and works with or without inhibitors
Emicizumab bridges factors IXa and X to replace factor VIIIa function and is effective in patients with inhibitors.