CSMLS Immunology and Serology Flashcards
6 cards from real CSMLS practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 6 CSMLS Immunology and Serology flashcards as text
Which immunoglobulin class is the first to be produced during a primary immune response?
Answer: IgM
IgM is the first antibody produced during a primary immune response due to its pentameric structure enabling early complement activation.
In an enzyme-linked immunosorbent assay (ELISA), the signal is generated by:
Answer: An enzyme conjugated to an antibody
In ELISA, an enzyme-conjugated antibody reacts with a substrate to produce a measurable colorimetric, fluorescent, or luminescent signal.
The complement pathway initiated by antigen-antibody complexes is the:
Answer: Classical pathway
The classical complement pathway is activated by antigen-antibody (immune) complexes binding to C1q.
A prozone phenomenon in agglutination testing occurs when:
Answer: Antibody is in excess causing false-negative results
The prozone effect occurs when antibody excess prevents lattice formation, resulting in a false-negative agglutination reaction.
Which serological test is the gold standard for confirming HIV infection?
Answer: Western blot
Western blot is used as the confirmatory test for HIV infection because it detects antibodies to specific viral proteins.
HLA typing in transplantation medicine is performed to:
Answer: Match donor and recipient tissue antigens to reduce rejection
HLA (human leukocyte antigen) typing matches major histocompatibility complex antigens between donor and recipient to minimize transplant rejection.