CRE CRE Pharmacology & Medications 2

Question 1

A valved holding chamber (spacer) used with an MDI primarily improves therapy by:

Accepted Answer

Improving drug deposition in the lower airways

Answer

Spacers slow the aerosol cloud, reduce particle velocity, and decrease oropharyngeal deposition, improving lower airway drug delivery.

Question 2

Which inhaled medication requires the patient to rinse their mouth after each use to prevent oral candidiasis?

Accepted Answer

Fluticasone (inhaled corticosteroid)

Answer

Inhaled corticosteroids deposited in the oropharynx suppress local immunity, promoting Candida overgrowth if the mouth is not rinsed.

Question 3

Long-acting beta-2 agonists (LABAs) carry an FDA black box warning against use as:

Accepted Answer

Monotherapy in asthma

Answer

LABA monotherapy in asthma is associated with increased risk of severe asthma-related death, requiring co-administration with an ICS.

Question 4

Which route of medication administration provides the most rapid systemic drug absorption?

Accepted Answer

Intravenous

Answer

Intravenous administration delivers medication directly into systemic circulation, bypassing all absorption barriers and providing the fastest onset.

Question 5

Mucolytics like N-acetylcysteine reduce mucus viscosity primarily by:

Accepted Answer

Breaking disulfide bonds in mucoproteins

Answer

N-acetylcysteine cleaves disulfide bonds within mucus glycoproteins, reducing the viscosity and elasticity of airway secretions.

(CRE) Certified Respiratory Educator Practice Test