CRE Pharmacology & Medications Flashcards
6 cards from real CRE practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 6 CRE Pharmacology & Medications flashcards as text
A valved holding chamber (spacer) used with an MDI primarily improves therapy by:
Answer: Improving drug deposition in the lower airways
Spacers slow the aerosol cloud, reduce particle velocity, and decrease oropharyngeal deposition, improving lower airway drug delivery.
Which inhaled medication requires the patient to rinse their mouth after each use to prevent oral candidiasis?
Answer: Fluticasone (inhaled corticosteroid)
Inhaled corticosteroids deposited in the oropharynx suppress local immunity, promoting Candida overgrowth if the mouth is not rinsed.
Long-acting beta-2 agonists (LABAs) carry an FDA black box warning against use as:
Answer: Monotherapy in asthma
LABA monotherapy in asthma is associated with increased risk of severe asthma-related death, requiring co-administration with an ICS.
Which route of medication administration provides the most rapid systemic drug absorption?
Answer: Intravenous
Intravenous administration delivers medication directly into systemic circulation, bypassing all absorption barriers and providing the fastest onset.
Mucolytics like N-acetylcysteine reduce mucus viscosity primarily by:
Answer: Breaking disulfide bonds in mucoproteins
N-acetylcysteine cleaves disulfide bonds within mucus glycoproteins, reducing the viscosity and elasticity of airway secretions.
Sildenafil is used in pulmonary arterial hypertension because it promotes pulmonary vasodilation by:
Answer: Inhibiting PDE-5 to increase cGMP levels
Sildenafil inhibits phosphodiesterase-5, preventing cGMP breakdown and sustaining nitric oxide–mediated pulmonary vasodilation.