CPJE CPJE Drug Interactions and Therapeutics

Question 1

A patient on warfarin is prescribed ciprofloxacin. Which monitoring parameter should the pharmacist prioritize?

Accepted Answer

INR/PT levels

Answer

Blood glucose

Answer

Serum potassium

Answer

Liver enzymes

Question 2

Which drug combination is contraindicated due to the risk of serotonin syndrome?

Accepted Answer

Sertraline and linezolid

Answer

Metformin and lisinopril

Answer

Atorvastatin and amlodipine

Answer

Omeprazole and clopidogrel

Question 3

A patient taking simvastatin is started on clarithromycin. What is the primary concern?

Accepted Answer

Increased risk of myopathy/rhabdomyolysis

Answer

Reduced antibiotic efficacy

Answer

Hyperkalemia

Answer

QT prolongation only

Question 4

Which interaction requires separating doses by at least 2 hours to prevent reduced drug absorption?

Accepted Answer

Levothyroxine and calcium carbonate

Answer

Metoprolol and amlodipine

Answer

Metformin and glipizide

Answer

Lisinopril and furosemide

Question 5

A patient on lithium is prescribed ibuprofen for pain. What adverse outcome is most likely?

Accepted Answer

Lithium toxicity due to elevated serum levels

Answer

Reduced lithium efficacy

Answer

Additive CNS depression

Answer

Hypokalemia

Question 6

Which mechanism explains the interaction between digoxin and amiodarone?

Accepted Answer

Amiodarone inhibits P-glycoprotein, increasing digoxin levels

Answer

Amiodarone induces CYP2D6, decreasing digoxin levels

Answer

Additive chronotropic effects reduce efficacy

Answer

Amiodarone displaces digoxin from plasma proteins