CPI Infection Control & Prevention 2

Question 1

In a clinical trial, a participant develops a catheter-associated urinary tract infection (CAUTI). Which organism is most commonly implicated in CAUTIs?

Accepted Answer

Escherichia coli

Answer

E. coli is the most common causative pathogen in catheter-associated urinary tract infections.

Question 2

A researcher notices that trial staff are not consistently performing hand hygiene between participant contacts. The MOST effective immediate intervention is:

Accepted Answer

Install alcohol-based hand rub dispensers at point-of-care

Answer

Point-of-care placement of alcohol-based hand rub dispensers is the most effective environmental intervention to improve hand hygiene compliance.

Question 3

Which of the following blood-borne pathogens has the highest transmission risk after a needlestick injury from an infected source?

Accepted Answer

Hepatitis B virus (HBV)

Answer

HBV has the highest transmission risk per needlestick (~30%), compared to ~3% for HCV and ~0.3% for HIV.

Question 4

A clinical trial site receives a shipment of investigational vaccines requiring storage at 2–8°C. Upon arrival, the refrigerator temperature log shows an excursion to 12°C overnight. The PI should FIRST:

Accepted Answer

Quarantine the vaccines and contact the sponsor

Answer

Vaccines affected by a temperature excursion must be quarantined and the sponsor contacted to assess viability before any use or disposal.

Question 5

Standard Precautions in a clinical research setting apply to:

Accepted Answer

All blood and body fluids regardless of diagnosis

Answer

Standard Precautions assume all blood and body fluids are potentially infectious and apply to every participant regardless of known infection status.

(CPI) Certified Physician Investigator Practice Test

(CPI) Certified Physician Investigator Practice Test

CPI Infection Control & Prevention 2