Infection Control & Prevention Flashcards
7 cards from real CPI practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Infection Control & Prevention flashcards as text
A clinical trial involves frequent blood draws from participants. Which of the following BEST reduces the risk of phlebotomy-related infections?
Answer: Employing single-use needles and proper site antisepsis
Single-use needles with proper skin antisepsis (e.g., 70% isopropyl alcohol) are the cornerstone of preventing phlebotomy-related infections.
Which infection surveillance metric is MOST useful for benchmarking infection rates across multiple clinical trial sites?
Answer: Infection rate per 1,000 participant-days
Infection rate per 1,000 participant-days accounts for varying enrollment sizes and follow-up durations, enabling valid cross-site comparisons.
A researcher finds that a participant in an immunosuppression trial tested positive for latent tuberculosis (LTBI) at screening. Before initiating the investigational drug, the MOST appropriate action is:
Answer: Consult with an infectious disease specialist and follow the protocol's guidance
Management of LTBI in immunosuppression trials should be guided by an infectious disease specialist and the protocol's pre-specified guidance for this scenario.
Which of the following is a key principle of the hierarchy of controls applied to infection prevention in clinical research?
Answer: Elimination of the hazard is the most effective control measure
In the hierarchy of controls, elimination of the hazard is the most effective strategy, followed by substitution, engineering controls, administrative controls, and PPE as the least effective.
A clinical trial site is preparing to enroll participants who will receive intrathecal injections. Which sterilization level is required for instruments used in this procedure?
Answer: Sterilization
Instruments entering sterile body spaces (critical items like intrathecal delivery devices) must be sterilized to eliminate all microbial life including spores.
In clinical research, which of the following is the PRIMARY purpose of performing an infection control risk assessment (ICRA) before a trial begins?
Answer: To identify and mitigate infection risks specific to the study procedures and population
An ICRA proactively identifies infection risks inherent to the study's procedures, participant population, and environment so that preventive measures can be implemented before enrollment.
A participant enrolled in a clinical trial develops varicella (chickenpox). Regarding infection control at the trial site, which action is MOST appropriate?
Answer: Implement Airborne and Contact Precautions
Varicella requires both Airborne Precautions (due to small-particle aerosol transmission) and Contact Precautions (due to direct contact with lesions).