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Compounding Flashcards

7 cards from real CPHT practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. Which type of water is required for reconstituting parenteral preparations in sterile compounding?

    Answer: Sterile Water for Injection USP

    Sterile Water for Injection (SWFI) USP is the standard diluent for parenteral products because it is both purified and rendered sterile and pyrogen-free.

  2. A compounded transdermal gel is prepared using PLO (pluronic lecithin organogel). The purpose of PLO is to:

    Answer: Enhance penetration of the drug through the skin

    PLO is a lipophilic gel base that facilitates transdermal drug absorption by improving drug penetration through the stratum corneum.

  3. Before discarding a returned or unused compounded hazardous drug preparation, the pharmacy technician should:

    Answer: Dispose of it via an EPA-compliant pharmaceutical waste vendor or reverse distributor

    Hazardous drug waste must be disposed of through regulated channels (e.g., Pharmaceutical Waste Rule-compliant containers and vendors) to protect public and environmental health.

  4. Osmolarity is a critical parameter when compounding ophthalmic preparations because:

    Answer: Solutions outside the isotonic range (approximately 285–310 mOsm/L) cause irritation or damage to ocular tissue

    Ophthalmic preparations must be near isotonic (approximately 285–310 mOsm/L) to avoid pain, irritation, and cellular damage to the delicate eye tissues.

  5. Which of the following represents a correct first-air principle when working inside a laminar airflow workbench (LAFW)?

    Answer: Never allow any object to interrupt the unidirectional airflow path between the HEPA filter and an open critical site

    First-air is the uncontaminated air directly from the HEPA filter; no object, including hands, should block this air from reaching an open vial, needle, or syringe tip.

  6. A technician is compounding a preparation that calls for 'qs ad 120 mL.' The preparation already contains 85 mL of liquid ingredients. How much solvent should be added?

    Answer: 35 mL

    'Qs ad 120 mL' means add sufficient quantity of solvent to make the total volume 120 mL; 120 − 85 = 35 mL.

  7. According to USP , personnel who compound sterile preparations must perform hand hygiene and garbing in which order?

    Answer: Hand hygiene → shoe covers → head cover → mask → gown → gloves

    USP specifies garbing from the most contaminated (feet) to the least contaminated (hands/gloves) areas: shoe covers, head cover, mask/face shield, gown, then hand hygiene and sterile gloves last.