CPC Inorganic Chemistry & Coordination Compounds 2

Question 1

Cisplatin is an effective anticancer drug while transplatin is not, primarily because cisplatin can:

Accepted Answer

Form intrastrand crosslinks between two adjacent guanine bases on DNA

Answer

Cross the cell membrane more rapidly due to higher lipophilicity

Answer

Be reduced to Pt(0) inside the nucleus to alkylate DNA

Answer

Directly inhibit RNA polymerase through square planar geometry

Question 2

Crystal Field Theory (CFT) accounts for the spectrochemical series by:

Accepted Answer

Treating ligands as point charges and ranking their ability to split d-orbital energies (Δ)

Answer

Calculating covalent orbital overlap between ligands and the metal center

Answer

Including π-backbonding contributions from the metal to empty ligand orbitals

Answer

Applying molecular orbital theory to determine metal–ligand bond order

Question 3

What is the Crystal Field Stabilization Energy (CFSE) for a strong-field (low-spin) d6 octahedral complex?

Accepted Answer

−2.4 Δo

Answer

−0.4 Δo

Answer

−2.0 Δo

Answer

−0.6 Δo

Question 4

Which of the following complexes exhibits optical isomerism?

Accepted Answer

[Co(en)3]3+

Answer

[Co(NH3)4Cl2]+

Answer

[Pt(NH3)2Cl2]

Answer

[CoCl4]2−

Question 5

The Jahn-Teller distortion is most pronounced for which d-electron configuration in an octahedral complex?

Accepted Answer

d9

Answer

d6 low-spin

Answer

d8

Answer

d3

Question 6

What is the hybridization of the central nickel atom in [Ni(CN)4]2−?

Accepted Answer

dsp2

Answer

sp3

Answer

sp3d

Answer

d2sp3

Question 7

Which of the following is classified as a π-acceptor (pi-acceptor) ligand?

Accepted Answer

CO

Answer

F−

Answer

H2O

Answer

NH3