CPAN Pharmacology Fundamentals 3

Question 1

Sugammadex reverses neuromuscular blockade by which mechanism?

Accepted Answer

Encapsulating and binding rocuronium or vecuronium

Answer

Sugammadex is a modified gamma-cyclodextrin that encapsulates steroidal NMB agents (rocuronium, vecuronium), forming a tight complex that renders them inactive.

Question 2

A PACU patient develops shivering post-anesthesia. Which medication is most commonly used to treat postoperative shivering?

Accepted Answer

Meperidine 25 mg IV

Answer

Low-dose meperidine (25 mg IV) is the most effective pharmacologic treatment for postoperative shivering, acting on kappa-opioid and alpha-2 receptors in the hypothalamus.

Question 3

Which of the following correctly describes the mechanism of ondansetron in preventing postoperative nausea and vomiting (PONV)?

Accepted Answer

Serotonin 5-HT3 receptor antagonist

Answer

Ondansetron blocks 5-HT3 (serotonin) receptors in the gut and CTZ, making it one of the most effective agents for PONV prophylaxis and treatment.

Question 4

A patient has a known allergy to sulfa drugs. Which non-opioid analgesic should be used with caution or avoided?

Accepted Answer

Celecoxib

Answer

Celecoxib is a COX-2 inhibitor containing a sulfonamide group and may cross-react in patients with sulfa drug allergies.

Question 5

Propofol infusion syndrome (PRIS) is most associated with which clinical finding?

Accepted Answer

Severe metabolic acidosis with cardiac failure

Answer

PRIS is characterized by severe metabolic (lactic) acidosis, rhabdomyolysis, cardiac failure, and renal failure, typically occurring with high-dose prolonged propofol infusions.

(CPAN) Certified Post Anesthesia Nurse Practice Test

(CPAN) Certified Post Anesthesia Nurse Practice Test

CPAN Pharmacology Fundamentals 3