COT Ophthalmic Pharmacology 5

Question 1

Which diagnostic dye is used to evaluate lacrimal drainage patency during the Jones dye tests?

Accepted Answer

Fluorescein sodium

Answer

Fluorescein sodium is instilled in the conjunctival sac for Jones I and II dye tests to assess whether dye passes through the nasolacrimal drainage system into the nasal cavity.

Question 2

Apraclonidine (Iopidine) is most commonly used in the ophthalmic setting to:

Accepted Answer

Prevent post-laser IOP spikes after anterior segment laser procedures

Answer

Apraclonidine is an alpha-2 agonist most commonly used perioperatively around laser treatments to blunt the acute IOP spike that can follow procedures such as laser iridotomy or trabeculoplasty.

Question 3

Which antiviral medication is the first-line topical treatment for herpes simplex epithelial keratitis?

Accepted Answer

Acyclovir ointment or trifluridine drops

Answer

Trifluridine 1% ophthalmic solution and acyclovir ointment are first-line topical antivirals used to treat active HSV epithelial (dendritic) keratitis.

Question 4

Natamycin ophthalmic suspension 5% is the drug of choice for treating which type of corneal infection?

Accepted Answer

Fungal (filamentous) keratitis caused by Fusarium or Aspergillus

Answer

Natamycin is a polyene antifungal that disrupts fungal cell membrane integrity and is the FDA-approved first-line topical treatment for filamentous fungal keratitis.

Question 5

The mechanism by which latanoprost lowers intraocular pressure is primarily by:

Accepted Answer

Increasing uveoscleral outflow via prostaglandin FP receptor activation

Answer

Latanoprost is a prostaglandin F2α analog that binds FP receptors in the ciliary muscle, increasing uveoscleral (unconventional) outflow to reduce IOP.

COT - Certified Ophthalmic Technician Practice Test

COT - Certified Ophthalmic Technician Practice Test

COT Ophthalmic Pharmacology 5