Cord Blood HLA Matching and Compatibility 2

Question 1

Which HLA loci are considered the MOST critical in cord blood unit selection?

Accepted Answer

HLA-A, B, and DRB1

Answer

HLA-A, B, and C only

Answer

HLA-DR and DQ only

Answer

HLA-DP and DQ only

Question 2

Which HLA typing method provides the highest resolution and most precise matching data?

Accepted Answer

High-resolution allele-level molecular typing

Answer

Serology-based typing

Answer

Low-resolution molecular typing

Answer

Flow cytometry-based typing

Question 3

A cord blood unit described as a 5/6 HLA match has a mismatch at which level?

Accepted Answer

One allele at one locus

Answer

Two alleles at two different loci

Answer

Three alleles across three loci

Answer

All alleles at one complete locus

Question 4

What does 'bidirectional HLA typing' evaluate in cord blood transplantation?

Accepted Answer

Assessing mismatches in both the graft-versus-host and host-versus-graft directions

Answer

Testing both donor and recipient HLA in the same laboratory

Answer

Matching one cord blood unit to two recipients simultaneously

Answer

Performing HLA typing at two separate facilities for confirmation

Question 5

How does a higher total nucleated cell (TNC) dose in a cord blood unit influence acceptable HLA mismatch levels?

Accepted Answer

Higher TNC dose allows greater HLA mismatches to be accepted

Answer

Higher TNC dose requires stricter HLA matching

Answer

TNC dose has no relationship to acceptable HLA mismatch

Answer

HLA mismatch and TNC dose are evaluated on entirely separate criteria

Question 6

What are cross-reactive groups (CREGs) in the context of HLA matching?

Accepted Answer

Clusters of HLA antigens sharing structural epitopes that may be immunologically cross-reactive

Answer

HLA antigens that trigger the strongest immune reactions

Answer

Groups of patients who react to the same cord blood units

Answer

HLA alleles found only in certain ethnic populations

Question 7

What is a 'permissive' HLA mismatch in cord blood transplantation?

Accepted Answer

A mismatch associated with acceptable clinical outcomes based on evidence

Answer

Any mismatch occurring at the HLA-C locus

Answer

A mismatch between HLA class I and class II antigens

Answer

A mismatch involving only rare HLA alleles