Cord Blood Cord Blood Stem Cells 3

Question 1

What is the graft-versus-leukemia (GVL) effect in cord blood transplantation?

Accepted Answer

Donor immune cells attacking residual leukemia cells in the recipient

Answer

The recipient's immune system attacking the graft

Answer

Leukemia cells destroying donor stem cells

Answer

A toxic reaction to the conditioning regimen

Question 2

Why might cord blood be preferred over matched unrelated donor (MUD) bone marrow for patients of mixed ethnic heritage?

Accepted Answer

HLA matching requirements for cord blood are less stringent, broadening donor options

Answer

Cord blood has no HLA antigens

Answer

Cord blood is always a perfect match

Answer

Cord blood does not require HLA typing

Question 3

What distinguishes autologous cord blood transplantation from allogeneic transplantation?

Accepted Answer

Autologous uses the patient's own stored cord blood; allogeneic uses a donor's cord blood

Answer

Autologous requires HLA matching; allogeneic does not

Answer

Autologous is only used for genetic diseases

Answer

Allogeneic uses private banks only

Question 4

What percentage of cord blood collections from full-term births typically meet the minimum cell count threshold for public banking?

Accepted Answer

About 20–30%

Answer

Nearly 100%

Answer

About 80%

Answer

Less than 5%

Question 5

Which of the following best describes the immunological naivety of cord blood T-cells?

Accepted Answer

They have not been exposed to foreign antigens and lack antigen-specific memory

Answer

They have memory of maternal antigens

Answer

They are fully activated effector cells

Answer

They express high levels of PD-1 exhaustion markers

Question 6

What is the role of natural killer (NK) cells derived from cord blood in anti-cancer therapy research?

Accepted Answer

They can kill cancer cells without prior sensitization and are being explored for adoptive cell therapy

Answer

They suppress the immune system after transplant

Answer

They produce erythropoietin

Answer

They are used only to prevent bacterial infections