Cord Blood Cord Blood Stem Cells 2

Question 1

What is the minimum total nucleated cell (TNC) dose per kilogram of recipient body weight typically required for successful cord blood engraftment?

Accepted Answer

2.5 × 10⁷ TNC/kg

Answer

1 × 10⁵ TNC/kg

Answer

3 × 10⁶ TNC/kg

Answer

1 × 10⁸ TNC/kg

Question 2

What is mixed chimerism following a cord blood transplant?

Accepted Answer

A mixture of both donor and recipient blood cells coexisting

Answer

100% donor cells in the recipient

Answer

Complete rejection of donor cells

Answer

Infection of the transplanted cells

Question 3

How long can cord blood stem cells be stored cryogenically while maintaining viability?

Accepted Answer

25 years or more

Answer

5 years maximum

Answer

10 years maximum

Answer

Only 1 year

Question 4

What is ex vivo expansion of cord blood stem cells designed to overcome?

Accepted Answer

The limited cell dose in a single cord blood unit

Answer

HLA mismatching

Answer

GVHD risk

Answer

Viral contamination

Question 5

Which cytokine combination is commonly used in ex vivo cord blood stem cell expansion protocols?

Accepted Answer

SCF, TPO, and Flt3 ligand

Answer

IL-2 and IL-4

Answer

TNF-alpha and IL-6

Answer

G-CSF and erythropoietin alone

Question 6

What are mesenchymal stem cells (MSCs) found in cord blood primarily known for?

Accepted Answer

Their immunomodulatory properties and ability to differentiate into bone, fat, and cartilage

Answer

Making red blood cells

Answer

Producing antibodies

Answer

Destroying cancer cells directly