COCN COCN Hematologic Malignancies

Question 1

Which type of leukemia is most commonly diagnosed in adults over 65 years old in the United States?

Accepted Answer

Chronic lymphocytic leukemia (CLL)

Answer

CLL is the most common adult leukemia in the US, predominantly affecting older adults.

Question 2

A patient with multiple myeloma is at highest risk for which skeletal complication?

Accepted Answer

Pathologic fractures

Answer

Myeloma cells stimulate osteoclasts and inhibit osteoblasts, leading to lytic lesions and pathologic fractures.

Question 3

The Philadelphia chromosome, resulting from a translocation between chromosomes 9 and 22, is the hallmark of which leukemia?

Accepted Answer

Chronic myeloid leukemia (CML)

Answer

The t(9;22) translocation creates the BCR-ABL fusion gene, which drives CML and is targeted by imatinib.

Question 4

Which staging system is used specifically for non-Hodgkin lymphoma and Hodgkin lymphoma?

Accepted Answer

Ann Arbor staging

Answer

The Ann Arbor staging system (Stages I–IV) classifies lymphoma based on the number and location of involved lymph node regions.

Question 5

A nurse is caring for a patient with multiple myeloma. Which lab finding is most indicative of disease activity?

Accepted Answer

Elevated serum protein electrophoresis (M-protein spike)

Answer

The M-protein spike on SPEP reflects the monoclonal immunoglobulin produced by malignant plasma cells.

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