CN Pharmacology & Drug Administration 2 — Questions and Answers
Question 1: Which term describes what the body does to a drug, including absorption, distribution, metabolism, and excretion?
- Pharmacodynamics
- Pharmacokinetics (Correct answer)
- Pharmacogenomics
- Bioavailability
Correct answer: Pharmacokinetics
Pharmacokinetics is the study of drug movement through the body (ADME).
Question 2: A client takes warfarin and consumes large amounts of vitamin K-rich greens. What is the likely effect?
- Increased anticoagulation
- Decreased anticoagulation (Correct answer)
- No interaction
- Enhanced drug absorption
Correct answer: Decreased anticoagulation
Vitamin K antagonizes warfarin, reducing its anticoagulant effect.
Question 3: Grapefruit juice can raise blood levels of certain drugs primarily by inhibiting which enzyme?
- CYP3A4 (Correct answer)
- Lipase
- Amylase
- Alcohol dehydrogenase
Correct answer: CYP3A4
Grapefruit inhibits intestinal CYP3A4, increasing systemic drug concentrations.
Question 4: Which route of administration generally provides the fastest onset of systemic effect?
- Oral
- Transdermal
- Intravenous (Correct answer)
- Subcutaneous
Correct answer: Intravenous
IV delivers the drug directly into the bloodstream, bypassing absorption.
Question 5: A statin depletes the body's synthesis of which nutrient-like compound?
- Coenzyme Q10 (Correct answer)
- Vitamin C
- Folate
- Biotin
Correct answer: Coenzyme Q10
Statins reduce CoQ10 synthesis via the same mevalonate pathway they block.
Question 6: Which mineral supplement can bind to tetracycline antibiotics and reduce their absorption?
- Potassium
- Calcium (Correct answer)
- Sodium
- Chloride
Correct answer: Calcium
Calcium chelates tetracyclines, decreasing antibiotic absorption.
Question 7: The 'first-pass effect' primarily reduces the bioavailability of drugs given by which route?
- Intravenous
- Oral (Correct answer)
- Inhalation
- Sublingual
Correct answer: Oral
Orally absorbed drugs pass through the liver first, where much is metabolized.
CN Pharmacology & Drug Administration 2
Which term describes what the body does to a drug, including absorption, distribution, metabolism, and excretion?