Practice Test GeeksCMC - Cardiac Medicine Certification Practice Test
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CMC Cardiac Pharmacology & Medications Flashcards

6 cards from real CMC practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. Clopidogrel prevents platelet aggregation by irreversibly blocking which receptor?

    Answer: P2Y12 ADP receptor

    Clopidogrel irreversibly blocks the P2Y12 ADP receptor, preventing ADP-induced platelet activation and aggregation.

  2. In warfarin-related life-threatening bleeding, which agents are used for rapid reversal?

    Answer: Vitamin K plus 4-factor prothrombin complex concentrate

    Warfarin emergencies require Vitamin K (slow, sustained reversal) plus 4-factor PCC (rapid replacement of clotting factors).

  3. Hydralazine combined with isosorbide dinitrate is indicated in heart failure patients who cannot tolerate which drug class?

    Answer: ACE inhibitors or ARBs

    Hydralazine-nitrate therapy is an evidence-based alternative for HF patients intolerant of renin-angiotensin system blockers.

  4. Sacubitril/valsartan (Entresto) improves outcomes in HFrEF by combining an ARB with inhibition of which enzyme?

    Answer: Neprilysin

    Sacubitril inhibits neprilysin, preventing degradation of natriuretic peptides, while valsartan blocks angiotensin II receptors.

  5. What is the specific antidote used to reverse unfractionated heparin-induced bleeding?

    Answer: Protamine sulfate

    Protamine sulfate is a positively charged protein that binds and neutralizes negatively charged heparin, reversing its anticoagulant effect.

  6. PCSK9 inhibitors like evolocumab lower LDL cholesterol by which mechanism?

    Answer: Preventing PCSK9 from degrading LDL receptors, increasing hepatic LDL clearance

    PCSK9 inhibitors prevent PCSK9 from degrading LDL receptors, allowing more receptors to clear LDL from circulation.