CLT CLT Wound Healing & Tissue Repair 2 — Questions and Answers
Question 1: The remodeling (maturation) phase of wound healing can last up to:
- 3 days
- 2 weeks
- 2 years (Correct answer)
- 6 hours
Correct answer: 2 years
The remodeling phase involves collagen cross-linking and scar maturation and can continue for up to 2 years following initial wound closure.
Question 2: How does low-level laser therapy (LLLT) affect fibroblast activity in wound healing?
- LLLT destroys fibroblasts
- LLLT stimulates fibroblast proliferation and collagen synthesis, accelerating tissue repair (Correct answer)
- LLLT has no effect on fibroblasts
- LLLT converts fibroblasts into macrophages
Correct answer: LLLT stimulates fibroblast proliferation and collagen synthesis, accelerating tissue repair
Low-level laser therapy stimulates fibroblast proliferation and increases collagen synthesis through photobiomodulation, directly accelerating the tissue repair process.
Question 3: Which wavelength range is considered most effective for promoting wound healing in deep tissue using laser therapy?
- 200–300 nm (UV range)
- 630–1000 nm (red to near-infrared range) (Correct answer)
- 1200–1500 nm (mid-infrared range)
- Above 10,000 nm (far-infrared range)
Correct answer: 630–1000 nm (red to near-infrared range)
The 630–1000 nm therapeutic window (red to near-infrared) penetrates tissue optimally and interacts with cytochrome c oxidase to stimulate cellular energy production and wound healing.
Question 4: What is wound contraction and which cell type drives this process?
- Wound contraction is wound enlargement driven by neutrophils
- It is the pulling together of wound edges, driven by myofibroblasts (Correct answer)
- Wound contraction is collagen dissolution driven by macrophages
- It is new epithelial growth driven by keratinocytes only
Correct answer: It is the pulling together of wound edges, driven by myofibroblasts
Wound contraction is the mechanical drawing together of wound margins, primarily driven by myofibroblasts—differentiated fibroblasts with smooth-muscle-like contractile properties.
Question 5: A wound with slough and necrotic tissue is considered to be in which wound healing state?
- Proliferative phase with active granulation
- A stalled or chronic wound requiring debridement before laser therapy can be maximally effective (Correct answer)
- Fully healed remodeling phase
- Hemostasis phase
Correct answer: A stalled or chronic wound requiring debridement before laser therapy can be maximally effective
Slough and necrotic tissue indicate a stalled wound; debridement is typically required to remove non-viable tissue before laser therapy can optimally stimulate healing.
Question 6: In diabetic wound healing, why is laser therapy particularly beneficial?
- It replaces insulin therapy
- It compensates for impaired microcirculation and cellular dysfunction by enhancing cellular energy (ATP) production and angiogenesis (Correct answer)
- It sterilizes the wound by killing all bacteria
- It has no special benefit for diabetic wounds
Correct answer: It compensates for impaired microcirculation and cellular dysfunction by enhancing cellular energy (ATP) production and angiogenesis
Diabetes impairs microcirculation and cellular metabolism; laser therapy's ability to boost mitochondrial ATP production and stimulate angiogenesis directly addresses these deficits.
CLT CLT Wound Healing & Tissue Repair 2
The remodeling (maturation) phase of wound healing can last up to: