CHT HLA Genetics & Molecular Biology

Question 1

Which chromosome carries the HLA gene complex in humans?

Accepted Answer

Chromosome 6

Answer

Chromosome 7

Answer

Chromosome 9

Answer

Chromosome 12

Question 2

Which HLA class II loci are considered the most polymorphic and clinically significant for transplantation?

Accepted Answer

HLA-DRB1 and HLA-DQB1

Answer

HLA-DPA1 and HLA-DPB1

Answer

HLA-DMA and HLA-DMB

Answer

HLA-DOA and HLA-DOB

Question 3

What term describes the tendency of certain HLA alleles to occur together on the same chromosome more often than expected by chance?

Accepted Answer

Linkage disequilibrium

Answer

Codominant expression

Answer

Haplotype shuffling

Answer

Allelic exclusion

Question 4

HLA molecules are encoded by genes in which genomic region?

Accepted Answer

Major Histocompatibility Complex (MHC)

Answer

T-cell receptor locus

Answer

Immunoglobulin heavy chain locus

Answer

Complement gene cluster

Question 5

Which feature of HLA class I molecules allows them to present endogenous peptides?

Accepted Answer

Peptide-binding groove formed by alpha-1 and alpha-2 domains

Answer

Peptide-binding groove formed by alpha-1 and beta-1 domains

Answer

Transmembrane domain complexed with beta-2 microglobulin

Answer

Variable CDR3 loop structure

Question 6

What is the inheritance pattern of HLA haplotypes?

Accepted Answer

Codominant Mendelian inheritance as a haplotype unit

Answer

X-linked dominant

Answer

Autosomal recessive only

Answer

Mitochondrial inheritance