Laboratory Management & Safety Flashcards
6 cards from real CHT practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 6 Laboratory Management & Safety flashcards as text
Which accreditation organization specifically accredits histocompatibility laboratories in the United States?
Answer: American Society for Histocompatibility and Immunogenetics (ASHI)
ASHI provides specialty accreditation for histocompatibility laboratories, setting standards specific to HLA testing, crossmatching, and transplant immunology beyond CLIA requirements.
Under CLIA regulations, which category applies to most HLA typing assays performed in histocompatibility labs?
Answer: High complexity
HLA typing assays require specialized training, complex interpretation, and quality oversight, placing them in the high complexity category under CLIA 88 regulations.
What is the required minimum qualification for a laboratory director of an ASHI-accredited histocompatibility laboratory?
Answer: PhD or MD with specific training and experience in histocompatibility and immunogenetics
ASHI standards require the laboratory director to hold a doctoral degree (PhD or MD) with documented training and competency specifically in histocompatibility and immunogenetics.
What does proficiency testing (PT) in a histocompatibility lab serve to demonstrate?
Answer: Laboratory competency in performing and interpreting HLA testing compared to peer labs
PT programs like those from CAP or ASHI send unknown samples to labs; correct results compared to peer laboratory consensus demonstrate ongoing testing proficiency as required by CLIA.
Which biological safety level (BSL) is appropriate for routine work with human blood and tissue specimens in a histocompatibility lab?
Answer: BSL-2
BSL-2 practices are standard for clinical labs handling human blood and tissues with potential exposure to bloodborne pathogens like HIV and HBV.
What is the purpose of a 'chain of custody' for samples in a histocompatibility laboratory?
Answer: To document the handling, transfer, and testing of specimens to ensure traceability and integrity
Chain of custody documentation tracks every person who handled a specimen and every step from collection to result, ensuring traceability and defending result integrity.