CFS History and Nomenclature Flashcards
6 cards from real CFS practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 6 CFS History and Nomenclature flashcards as text
What were the 1994 CDC (Fukuda) diagnostic criteria for CFS primarily based on?
Answer: Clinically evaluated, unexplained fatigue plus 4 of 8 specified symptoms
The 1994 Fukuda criteria required clinically evaluated, unexplained fatigue lasting 6+ months plus at least 4 of 8 specified symptoms such as cognitive impairment, sore throat, and post-exertional malaise.
What major criticism was leveled at the 1994 Fukuda criteria for CFS?
Answer: PEM was not required, potentially including patients without the hallmark symptom
A major criticism of the Fukuda criteria was that post-exertional malaise was not a required symptom, meaning patients without this hallmark of CFS could still receive the diagnosis.
What were the 2003 Canadian Consensus Criteria (CCC) designed to achieve?
Answer: Create a more specific clinical definition requiring PEM as a core feature
The Canadian Consensus Criteria were designed to create a more specific clinical definition that required PEM as a core feature, aiming to identify a more homogeneous patient population.
What was the 'XMRV controversy' in CFS research?
Answer: A retracted 2009 study claiming a link between XMRV retrovirus and CFS that could not be replicated
The 2009 Science paper claiming a link between XMRV retrovirus and CFS generated enormous hope but was later retracted after multiple labs failed to replicate the findings.
What are the 2015 IOM diagnostic criteria for ME/CFS notable for requiring?
Answer: Post-exertional malaise, unrefreshing sleep, and cognitive impairment as core required features
The 2015 IOM criteria made PEM, unrefreshing sleep, and cognitive impairment required core features, representing a more biologically grounded definition than previous criteria.
Which federal agency in the US funds most CFS/ME research and has historically been criticized for underfunding it?
Answer: NIH (National Institutes of Health)
The NIH funds most CFS/ME research in the US and has faced criticism from advocates for historically low funding levels relative to the disease burden.