CFS CFS History and Nomenclature 2

Question 1

What were the 1994 CDC (Fukuda) diagnostic criteria for CFS primarily based on?

Accepted Answer

Clinically evaluated, unexplained fatigue plus 4 of 8 specified symptoms

Answer

The 1994 Fukuda criteria required clinically evaluated, unexplained fatigue lasting 6+ months plus at least 4 of 8 specified symptoms such as cognitive impairment, sore throat, and post-exertional malaise.

Question 2

What major criticism was leveled at the 1994 Fukuda criteria for CFS?

Accepted Answer

PEM was not required, potentially including patients without the hallmark symptom

Answer

A major criticism of the Fukuda criteria was that post-exertional malaise was not a required symptom, meaning patients without this hallmark of CFS could still receive the diagnosis.

Question 3

What were the 2003 Canadian Consensus Criteria (CCC) designed to achieve?

Accepted Answer

Create a more specific clinical definition requiring PEM as a core feature

Answer

The Canadian Consensus Criteria were designed to create a more specific clinical definition that required PEM as a core feature, aiming to identify a more homogeneous patient population.

Question 4

What was the 'XMRV controversy' in CFS research?

Accepted Answer

A retracted 2009 study claiming a link between XMRV retrovirus and CFS that could not be replicated

Answer

The 2009 Science paper claiming a link between XMRV retrovirus and CFS generated enormous hope but was later retracted after multiple labs failed to replicate the findings.

Question 5

What are the 2015 IOM diagnostic criteria for ME/CFS notable for requiring?

Accepted Answer

Post-exertional malaise, unrefreshing sleep, and cognitive impairment as core required features

Answer

The 2015 IOM criteria made PEM, unrefreshing sleep, and cognitive impairment required core features, representing a more biologically grounded definition than previous criteria.

CFS - Chronic Fatigue Syndrome Practice Test

CFS - Chronic Fatigue Syndrome Practice Test

CFS CFS History and Nomenclature 2