CFC Toxicology & Drug Analysis 2

Question 1

Which analytical technique is considered the gold standard for confirming the identity of an unknown drug in forensic toxicology?

Accepted Answer

Gas chromatography-mass spectrometry (GC-MS)

Answer

GC-MS combines separation with definitive molecular identification and is universally accepted as the confirmatory gold standard in forensic drug analysis.

Question 2

A victim's blood sample shows elevated carboxyhemoglobin levels. What toxicant is most likely responsible?

Accepted Answer

Carbon monoxide

Answer

Carbon monoxide binds hemoglobin to form carboxyhemoglobin, and elevated levels (>10%) are diagnostic of CO exposure.

Question 3

In postmortem redistribution, drug concentrations in which specimen are most affected by site-dependent changes?

Accepted Answer

Central blood (cardiac)

Answer

Central blood from the heart and great vessels is most susceptible to postmortem redistribution due to proximity to drug-rich organs like the liver and lungs.

Question 4

Which enzyme immunoassay cross-reacts most problematically with over-the-counter cold medications to produce false-positive amphetamine screens?

Accepted Answer

Ephedrine and pseudoephedrine

Answer

Ephedrine and pseudoephedrine share structural similarity with amphetamines and frequently cause false-positive immunoassay screens for amphetamines.

Question 5

What is the primary metabolite of cocaine detected in urine drug screens?

Accepted Answer

Benzoylecgonine

Answer

Benzoylecgonine is the major urinary metabolite of cocaine, persisting 2–4 days after use and targeted by immunoassay screens.

(CFC) Certified Forensic Consultant Practice Test

(CFC) Certified Forensic Consultant Practice Test

CFC Toxicology & Drug Analysis 2