A frail 82-year-old under moderate sedation for EGD develops shallow respirations at 6 breaths per minute. Which age-related change most contributes to this complication?
-
A
Decreased drug clearance and increased sensitivity to sedatives
-
B
Increased hepatic metabolism of benzodiazepines
-
C
Higher baseline respiratory reserve
-
D
Reduced blood-brain barrier permeability to opioids