Certified Gastroenterology RN Gastroenterology Pharmacology 4

Question 1

A patient scheduled for colonoscopy is prescribed polyethylene glycol solution; which finding warrants holding the prep and calling the provider?

Accepted Answer

Severe abdominal distention and inability to pass flatus

Answer

Distention with obstipation suggests bowel obstruction, a contraindication to osmotic bowel preparation.

Question 2

Which drug interaction is most concerning for a patient taking omeprazole with clopidogrel?

Accepted Answer

Reduced antiplatelet effect via CYP2C19 inhibition

Answer

Omeprazole inhibits CYP2C19, which is required to convert clopidogrel into its active antiplatelet metabolite.

Question 3

A patient with irritable bowel syndrome with constipation (IBS-C) may be prescribed which chloride channel activator?

Accepted Answer

Lubiprostone

Answer

Lubiprostone activates intestinal chloride channels, increasing fluid secretion and accelerating transit in IBS-C.

Question 4

Alosetron carries a boxed warning for which serious adverse effect in IBS-D patients?

Accepted Answer

Ischemic colitis

Answer

Alosetron can cause ischemic colitis and severe constipation, so it is restricted to women with severe IBS-D under a special program.

Question 5

Which instruction is correct for a patient taking a bile acid sequestrant such as cholestyramine?

Accepted Answer

Take other medications 1 hour before or 4-6 hours after the sequestrant

Answer

Cholestyramine binds many drugs in the gut, so other medications must be separated to avoid impaired absorption.

Certified Gastroenterology RN Practice Test