CCTN Post-Transplant Immunosuppressive Medications 3

Question 1

When should a transplant nurse administer the morning dose of tacrolimus relative to blood draws for trough levels?

Accepted Answer

After the blood draw is collected

Answer

Before the blood draw is collected

Answer

It does not matter — timing has no effect on levels

Answer

Two hours after the blood draw

Question 2

Which immunosuppressant is most associated with new-onset diabetes after transplantation (NODAT)?

Accepted Answer

Tacrolimus

Answer

Mycophenolate mofetil

Answer

Sirolimus

Answer

Azathioprine

Question 3

A heart transplant patient is prescribed azathioprine. What lab value requires close monitoring?

Accepted Answer

Complete blood count (CBC)

Answer

Serum potassium

Answer

Serum creatinine

Answer

Serum calcium

Question 4

Which statement accurately describes maintenance immunosuppression in transplantation?

Accepted Answer

It consists of lifelong medications to prevent rejection

Answer

It is given only during rejection episodes

Answer

It is weaned off after 1 year post-transplant

Answer

It is only required for high-immunologic-risk patients

Question 5

A patient taking tacrolimus is prescribed rifampin for tuberculosis. What effect should the transplant nurse anticipate?

Accepted Answer

Tacrolimus levels will decrease significantly due to CYP3A4 induction

Answer

Tacrolimus levels will increase significantly

Answer

Rifampin has no effect on tacrolimus levels

Answer

Tacrolimus will be contraindicated and must be stopped

Question 6

What is the rationale for using triple immunosuppression therapy in most solid organ transplant protocols?

Accepted Answer

To block multiple pathways of immune activation while minimizing individual drug toxicity

Answer

To reduce cost by using lower doses of each drug

Answer

To ensure at least one drug is effective if one fails

Answer

To comply with UNOS regulations