CCTC Organ Procurement and Preservation 2

Question 1

Which component of University of Wisconsin (UW) solution primarily prevents cellular swelling during cold storage?

Accepted Answer

Lactobionate

Answer

Glucose

Answer

Albumin

Answer

Heparin

Question 2

What is the primary mechanism of organ injury during reperfusion following cold ischemia?

Accepted Answer

Generation of reactive oxygen species causing oxidative damage

Answer

Hyperacute rejection mediated by preformed antibodies

Answer

Activation of the adaptive immune response

Answer

Bacterial infection from contaminated preservation solution

Question 3

Machine perfusion of kidneys offers which primary advantage over static cold storage?

Accepted Answer

Allows continuous viability assessment and active removal of ischemic byproducts

Answer

Eliminates the need for HLA matching

Answer

Reduces post-transplant immunosuppression requirements

Answer

Decreases the risk of surgical complications at implantation

Question 4

What is the generally accepted maximum cold ischemia time for a cardiac transplant?

Accepted Answer

4–6 hours

Answer

8–12 hours

Answer

18–24 hours

Answer

24–36 hours

Question 5

Compared to DBD (donation after brain death) organs, DCD organs have a higher risk of which complication?

Accepted Answer

Delayed graft function

Answer

Hyperacute rejection

Answer

Chronic allograft nephropathy

Answer

CMV infection

Question 6

Which term describes the period when a DCD organ is at body temperature without adequate blood flow before cold flush?

Accepted Answer

Primary warm ischemia

Answer

Cold ischemia

Answer

Secondary ischemia

Answer

Normothermic perfusion

Question 7

What is the typical maximum cold ischemia time for a liver transplant to achieve acceptable outcomes?

Accepted Answer

12–24 hours

Answer

4–6 hours

Answer

30–36 hours

Answer

48–60 hours