Drug Therapy Management Flashcards
7 cards from real CCP practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Drug Therapy Management flashcards as text
An elderly patient with heart failure is prescribed spironolactone. Which monitoring parameter is most critical?
Answer: Serum potassium
Spironolactone is a potassium-sparing diuretic that can cause hyperkalemia, which is especially dangerous in heart failure patients.
A consultant pharmacist identifies that a nursing home resident on warfarin has an INR of 4.8 with no signs of bleeding. What is the most appropriate initial intervention?
Answer: Hold warfarin and recheck INR in 1-2 days
For supratherapeutic INR without serious bleeding, holding warfarin and rechecking the INR in 1-2 days is the standard approach per CHEST guidelines.
Which medication class is considered first-line therapy for reducing cardiovascular events in type 2 diabetes patients with established atherosclerotic cardiovascular disease?
Answer: GLP-1 receptor agonists or SGLT-2 inhibitors
ADA guidelines recommend GLP-1 receptor agonists or SGLT-2 inhibitors with proven cardiovascular benefit as preferred add-on therapy in T2DM with ASCVD.
A patient taking methotrexate for rheumatoid arthritis should receive supplementation with which vitamin to reduce toxicity?
Answer: Folic acid
Folic acid supplementation reduces methotrexate-associated adverse effects such as mucositis, nausea, and hepatotoxicity without reducing efficacy.
Which antibiotic class is associated with QT prolongation and should be used cautiously in patients on antipsychotics?
Answer: Fluoroquinolones
Fluoroquinolones prolong the QT interval and can have an additive effect when combined with antipsychotics, increasing the risk of torsades de pointes.
A long-term care resident on bisphosphonate therapy for osteoporosis reports new jaw pain following a dental procedure. What condition should be suspected?
Answer: Osteonecrosis of the jaw
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious adverse effect characterized by exposed jaw bone after dental procedures.
Which pharmacokinetic change associated with aging most significantly affects the dosing of lipid-soluble drugs in elderly patients?
Answer: Increased volume of distribution due to increased body fat
Aging increases the proportion of body fat relative to lean mass, expanding the volume of distribution for lipid-soluble drugs and prolonging their half-life.