A nurse in a correctional facility is evaluating an inmate's risk for cardiovascular disease using the ACC/AHA pooled cohort equations. Which combination of factors increases calculated 10-year risk most significantly?
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A
Female sex, age 35, non-smoker, LDL 110 mg/dL
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B
Male sex, age 58, smoker, systolic BP 155, total cholesterol 240 mg/dL
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C
Male sex, age 40, controlled hypertension, non-smoker
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D
Female sex, age 50, non-smoker, well-controlled diabetes