Practice Test Geeks(CCDM) Certified Clinical Data Manager Practice Test
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Statistical Analysis Flashcards

7 cards from real CCDM practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

Read the first 7 Statistical Analysis flashcards as text

  1. What is the primary purpose of stratified randomization in a clinical trial?

    Answer: To ensure balance of key prognostic factors across treatment groups

    Stratified randomization ensures that important prognostic variables are balanced between treatment arms, reducing confounding.

  2. A Type II error (beta error) in hypothesis testing refers to:

    Answer: Failing to reject the null hypothesis when it is actually false

    A Type II error (false negative) occurs when a study fails to detect a true treatment effect that actually exists.

  3. Which imputation method for missing data assumes data are Missing at Random (MAR) and uses all available data to estimate missing values?

    Answer: Multiple imputation

    Multiple imputation creates several plausible datasets under the MAR assumption, analyzes each, and pools results using Rubin's rules.

  4. The Bonferroni correction for multiple comparisons adjusts the significance threshold by:

    Answer: Dividing alpha by the number of comparisons

    The Bonferroni correction divides the family-wise alpha level by the number of tests to control the overall Type I error rate.

  5. What does NNT (Number Needed to Treat) measure in clinical research?

    Answer: The number of patients who must be treated to prevent one additional adverse outcome

    NNT is the reciprocal of the absolute risk reduction and quantifies the clinical impact of a treatment in practical terms.

  6. In a dose-response study, which statistical model is most appropriate for evaluating a monotonic relationship between dose and a continuous outcome?

    Answer: Linear trend test or regression

    A linear trend test or regression analysis evaluates whether increasing dose is associated with a consistent directional change in a continuous outcome.

  7. Which term describes the situation where the effect of treatment differs significantly across subgroups of patients?

    Answer: Effect modification (interaction)

    Effect modification, or statistical interaction, occurs when treatment efficacy varies by the level of another variable such as age or disease severity.