CBIC Antimicrobial Stewardship 3

Question 1

Which antibiotic class is associated with the highest risk of selecting for extended-spectrum beta-lactamase (ESBL)-producing organisms?

Accepted Answer

Third-generation cephalosporins

Answer

Third-generation cephalosporins exert strong selective pressure for ESBL-producing Enterobacterales, particularly in healthcare settings.

Question 2

An ASP intervention that requires infectious disease approval before dispensing certain restricted antibiotics is called:

Accepted Answer

Formulary restriction with prior authorization

Answer

Formulary restriction with prior authorization requires approval from an ID physician or pharmacist before restricted antibiotics can be dispensed.

Question 3

What is the recommended duration of antibiotic therapy for uncomplicated community-acquired pneumonia (CAP) in a hospitalized patient per current IDSA guidelines?

Accepted Answer

5 days if clinical improvement is achieved

Answer

Current IDSA guidelines support 5-day courses for CAP when the patient achieves clinical stability, reducing unnecessary antibiotic exposure.

Question 4

Which of the following is a key pharmacokinetic/pharmacodynamic (PK/PD) concept important to antimicrobial stewardship?

Accepted Answer

Time-dependent killing means beta-lactam efficacy depends on time above the MIC, not peak concentration

Answer

Beta-lactams exhibit time-dependent killing; their efficacy is maximized when drug concentration exceeds the MIC for a sufficient percentage of the dosing interval.

Question 5

Which of the following interventions is an example of an IV-to-oral (IV-to-PO) switch program within ASP?

Accepted Answer

Transitioning stable patients from IV vancomycin to oral linezolid when oral bioavailability is adequate

Answer

IV-to-PO switch programs reduce costs, catheter-related complications, and length of stay by transitioning clinically stable patients to oral agents with adequate bioavailability.

CBIC - Certification Board of Infection Control Practice Test

CBIC - Certification Board of Infection Control Practice Test

CBIC Antimicrobial Stewardship 3