CADC Pharmacology of Substance Abuse 2

Question 1

Which neurotransmitter system is primarily responsible for the reinforcing effects of most addictive substances?

Accepted Answer

Dopamine

Answer

Serotonin

Answer

GABA

Answer

Acetylcholine

Question 2

A client reports using heroin daily for two years. Which opioid receptor type is most responsible for heroin's analgesic and euphoric effects?

Accepted Answer

Mu (μ)

Answer

Kappa (κ)

Answer

Delta (δ)

Answer

Sigma (σ)

Question 3

Naloxone reverses opioid overdose by acting as a:

Accepted Answer

Competitive antagonist at opioid receptors

Answer

Partial agonist at mu receptors

Answer

Full agonist at kappa receptors

Answer

Reuptake inhibitor of dopamine

Question 4

Which statement best describes cross-tolerance in substance abuse pharmacology?

Accepted Answer

Tolerance developed to one drug that reduces the effect of a pharmacologically similar drug

Answer

Tolerance to one drug causing increased sensitivity to unrelated drugs

Answer

Two drugs producing opposite effects when combined

Answer

A drug losing effectiveness due to metabolic changes only

Question 5

The phenomenon where a drug produces progressively stronger effects with repeated administration at the same dose is called:

Accepted Answer

Sensitization (reverse tolerance)

Answer

Tolerance

Answer

Tachyphylaxis

Answer

Pharmacodynamic tolerance

Question 6

Which route of drug administration produces the fastest onset of action and highest peak blood concentration?

Accepted Answer

Intravenous injection

Answer

Oral ingestion

Answer

Intranasal (snorting)

Answer

Transdermal patch

Question 7

Alcohol primarily exerts its CNS depressant effects by:

Accepted Answer

Enhancing GABA-A receptor activity and inhibiting NMDA glutamate receptors

Answer

Blocking dopamine reuptake transporters

Answer

Stimulating serotonin 5-HT3 receptors exclusively

Answer

Activating mu opioid receptors