CAADE Pharmacology of Substances 3

Question 1

Which route of administration produces the fastest onset of drug effects?

Accepted Answer

Intravenous injection

Answer

Intravenous injection delivers the drug directly into the bloodstream, bypassing absorption barriers and producing onset within seconds.

Question 2

PCP (phencyclidine) produces its dissociative effects primarily through which mechanism?

Accepted Answer

Antagonism at NMDA glutamate receptors

Answer

PCP acts as an NMDA receptor antagonist, blocking glutamate activity and causing dissociation, hallucinations, and anesthesia.

Question 3

What is the mechanism by which naloxone reverses opioid overdose?

Accepted Answer

It competitively displaces opioids from mu-opioid receptors as an antagonist

Answer

Naloxone is a competitive mu-opioid receptor antagonist that displaces opioids from receptors, rapidly reversing respiratory depression and sedation.

Question 4

Which of the following best describes a 'set and setting' influence on drug effects?

Accepted Answer

The user's mindset and physical environment, which shape subjective drug experience

Answer

Set and setting, coined by Timothy Leary, refers to the user's mental state (set) and physical/social environment (setting) as key factors shaping drug experience.

Question 5

Chronic heavy alcohol use leads to nutritional deficiency of thiamine (B1), which can cause which neurological condition?

Accepted Answer

Korsakoff's syndrome and Wernicke's encephalopathy

Answer

Thiamine deficiency from chronic alcohol use causes Wernicke's encephalopathy (acute) and Korsakoff's syndrome (chronic amnestic disorder).

(CAADE) California Association for Alcohol/Drug Educators Certification Practice Test

(CAADE) California Association for Alcohol/Drug Educators Certification Practice Test

CAADE Pharmacology of Substances 3