Biology Test Immunology 3

Question 1

Which cells are considered the 'professional' antigen-presenting cells (APCs) most efficient at activating naive T cells?

Accepted Answer

Dendritic cells

Answer

Neutrophils

Answer

NK cells

Answer

Basophils

Question 2

What is clonal deletion in the context of T cell development?

Accepted Answer

Elimination of self-reactive T cells in the thymus

Answer

Proliferation of T cells after activation

Answer

Removal of exhausted T cells from circulation

Answer

Reduction of memory T cells over time

Question 3

Which antibody isotype is most abundant in mucosal secretions such as saliva and breast milk?

Accepted Answer

IgA

Answer

IgG

Answer

IgM

Answer

IgE

Question 4

What does the term 'somatic hypermutation' refer to in B cell biology?

Accepted Answer

Targeted mutations in immunoglobulin variable regions to increase antibody affinity

Answer

Random mutations throughout the B cell genome

Answer

Deletion of autoreactive B cell clones

Answer

Class switching from IgM to IgG

Question 5

Which pattern recognition receptor is responsible for detecting lipopolysaccharide (LPS) from gram-negative bacteria?

Accepted Answer

TLR4

Answer

TLR3

Answer

NOD2

Answer

RIG-I

Question 6

What is the mechanism of action of cytotoxic T lymphocytes (CTLs) when killing infected cells?

Accepted Answer

Releasing perforin and granzymes to induce apoptosis

Answer

Secreting antibodies that neutralize viruses

Answer

Activating complement on target cell surfaces

Answer

Engulfing and digesting infected cells

Question 7

In which disease would you expect to find elevated IgE levels and eosinophilia?

Accepted Answer

Allergic asthma

Answer

Multiple sclerosis

Answer

Systemic lupus erythematosus

Answer

Type 1 diabetes